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Briefly, a total of 15 healthy male common marmosets (Callithrix jacchus; 2 years old; 230–395 g) were randomly assigned into 5 groups. For measurement of prophylactic efficacy, common marmosets (3 per group) were intraperitoneally inoculated with 5 or 20 mg/kg of purified MCA1 at 24 hours before intratracheal challenge with 5 × 106 TCID50 of MERSCoV in 500  μL of DMEM.An irrelevant human immunoglobulin G (IgG) was used as a control.

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病毒在肺，气管中复制，肺炎